Cadence, a clinical AI company focused on chronic disease management for older adults, has announced a $100 million Series C financing round led by Spark Capital. The investment comes as the company continues to expand its AI-enabled care model across leading U.S. health systems and seeks to address growing demand for chronic care management amid ongoing clinician workforce shortages.
Alongside the financing, Cadence announced new affiliations with Duke Health and Texas Health Resources. The company now works with more than 20 health systems nationwide and manages care for over 100,000 active patients. Cadence also reported that it tripled annual recurring revenue during 2025.
“We believe the most consequential AI companies of the next decade will be built in categories where the technology changes the underlying mechanics of the business. Cadence has done the hardest work first – demonstrating clinical outcomes, building trust with the country's leading health systems, and proving out the safe and effective deployment of AI inside care delivery,” said Will Reed, partner at Spark Capital and new Cadence board member. “There is no other AI care platform in the country with this combination of scale, peer-reviewed clinical outcomes, and economic proof.”
Cadence’s platform is integrated directly into partner health systems’ medical groups, electronic medical records and clinical workflows. The company’s supervised AI agents continuously monitor patient health data, identify emerging risks, support medication management and provide personalized coaching between clinical visits. The model is designed to extend healthcare teams while enabling earlier intervention for patients with chronic conditions.
“At Duke Health, our mission is to advance the health of our patients and the communities we serve. The moments that matter most for a patient's health often happen at home, not in the clinic,” said Jeffrey Ferranti, MD, MS, Senior Vice President and Chief Digital Officer of Duke Health. “With Cadence, we stay connected to patients with chronic conditions around the clock, monitoring their health continuously so we can intervene early and keep them healthy.”
According to the company, median response time for incoming vital-sign alerts is 3.5 minutes, while 55% of alerts are resolved without human intervention. Cadence cited published and real-world results showing improvements in chronic disease management, including increased adherence to heart failure therapies, improved blood pressure control, reduced hospital admissions and lower overall healthcare costs.
“We built Cadence to solve the clinical labor constraint at the heart of the chronic disease crisis,” said Chris Altchek, founder and CEO of Cadence. “This investment builds the infrastructure to treat millions.”
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